9/2/2023 0 Comments Binocular diplopia![]() Statin-associated eye problems appear to be rare, but they have been reported as side effects. Moreover, some studies suggest that statins play a role in increasing the risk of diabetes mellitus, cancer, dementia, polyneuropathy, hemorrhagic stroke, and kidney disease. These adverse events include myalgia, myositis , rhabdomyolysis (0.1%), and elevated liver enzymes (1%). Statins are generally well-tolerated medications however, many adverse events ranging from mild to severe in impact have been associated with their use. Due to the inhibition of isoprenoid intermediates synthesis of the mevalonate pathway, statins have also shown some non-lipid-lowering effects, such as improving endothelial function, atherosclerotic plaque stabilization, as well as anti-inflammatory and immunomodulatory effects. It is reported that statins can reduce up to 20-55% of circulating LDL-C levels . This in turn increases the production of microsomal HMG-CoA reductase and cell surface low-density lipoprotein (LDL) receptor expression. ![]() Statins work by competitively blocking this enzyme, thereby leading to a decreased conversion of HMG-CoA to mevalonic acid . HMG-CoA reductase is the first and key-limiting enzyme in hepatic cholesterol synthesis. ![]() Their use has been progressively on the rise since 1992 in light of several studies on their role in primary and secondary prevention of coronary heart disease, stroke, and other causes of death associated with high cholesterol levels. 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (HMG-CoA reductase), commonly known as statins, constitute the first-line therapy for treating hypercholesterolemia.
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9/2/2023 0 Comments Funny news headlines 2020On an individual scale, the ability to actively confront false narratives, as well as taking care when sharing information can reduce the prevalence of falsified information. Politicians in certain autocratic and democratic countries have demanded effective self-regulation and legally-enforced regulation in varying forms, of social media and web search engines. Multiple strategies for fighting fake news are currently being actively researched, for various types of fake news. It has been increasingly criticized, due in part to Trump's misuse, with the British government deciding to avoid the term, as it is "poorly-defined" and "conflates a variety of false information, from genuine error through to foreign interference". president Donald Trump has been credited with popularizing the term by using it to describe any negative press coverage of himself. The term has at times been used to cast doubt upon credible news, and former U.S. It also particularly has the potential to undermine trust in serious media coverage. presidential election received more engagement on Facebook than top stories from major media outlets. For example, a BuzzFeed News analysis found that the top fake news stories about the 2016 U.S. įake news can reduce the impact of real news by competing with it. Several factors have been implicated in the spread of fake news, such as political polarization, post-truth politics, motivated reasoning, confirmation bias, and social media algorithms. The prevalence of fake news has increased with the recent rise of social media, especially the Facebook News Feed, and this misinformation is gradually seeping into the mainstream media. Because of this diversity of types of false news, researchers are beginning to favour information disorder as a more neutral and informative term. In some definitions, fake news includes satirical articles misinterpreted as genuine, and articles that employ sensationalist or clickbait headlines that are not supported in the text. Further, disinformation involves spreading false information with harmful intent and is sometimes generated and propagated by hostile foreign actors, particularly during elections. It's also been used by high-profile people to apply to any news unfavourable to them. Nevertheless, the term does not have a fixed definition and has been applied broadly to any type of false information. Although false news has always been spread throughout history, the term "fake news" was first used in the 1890s when sensational reports in newspapers were common. ![]() Fake news often has the aim of damaging the reputation of a person or entity, or making money through advertising revenue. Reporters with various forms of "fake news" from an 1894 illustration by Frederick Burr Opperįake news is false or misleading information presented as news. ![]() You’ll also have to do some extra clicking and typing to access these manuscript templates (unlike some of the other sites listed in this article). While you can access five templates for free, any additional access to other styles will have to be purchased. These templates offer different designs, not just your standard text and format options. This site offers 5 free minimal book layout templates that you can use with a variety of programs, Word included. You can check out their specifications, and even download their Book Printing Preparation Checklist PDF. If you need additional instructions, BookBaby offers some helpful information in the “Using Our Templates” section. Once you unzip the file, you can then open the Word book template (it will be the file that ends in “.doc”). zip file will then download to your computer, and it contains the template file. Once you find the correct size for your book, you can download the free book layout template by clicking the orange “Download” button underneath the corresponding size. The common standard sizing for most printed books is the US Trade 6” x 9” which is listed under the Interior Text Templates category. With several different sizes to choose from, BookBaby offers a variety of book layout templates depending on the type of book you are writing.įrom standard book sizes to niche-specific sizing options, you’ll want to be clear on which type of book template size you need for your story. ![]() Writing a Book: Template For Nonfiction.Here's where you can download a free template for book writing: When writing a book, templates are helpful to keep you on track and plan for which content your book needs to include. If you're writing a book and need a template to help you organize your chapters, content, and format, then we have a book template for you! These sites offer free, downloadable book templates for Microsoft Word. You can download the template, then open it in Word, and get to writing! There are several sites that offer free downloadable book templates, and they are already set-up and formatted specifically for writing a book. If you don't want to fuss with setting up a book template in Word, or want more variety in templates to chose from, consider downloading a pre-made book template for Word. It has several formatting options and includes free templates.It has a powerful document editor for spelling and grammar checks.It's versatile for use on a variety of word processing projects.It is readily available on most computers, and can be purchased at major retailers.Here's 5 reasons why you should use a book template to write your book: Ready to find your perfect Microsoft Word book manuscript template? Here we go! It’s readily available, user-friendly, and has all the nuts and bolts you need (including a powerful editor). If you don’t need a fancy writing software, or are just getting started as an author on a low budget, Microsoft Word may be your best bet. It’s your standard word processor, and while it seems basic, it’s super versatile and easy to use. Reasons to use a book templateĮvery author has their preference on writing tools, and one that continually tops the chart is Microsoft Word. In this article, we are simply listing the free book template resources that self-published authors can utilize as they write a book. This article does not review the quality of the services provided by these sites, so we aren’t able to provide any endorsement or testament as to whether these companies are good to work with or not. Please note that several of the sites listed here offer book production services. Since self-publishing costs come out of the author's own pocket, it's important to save money where you can, so that you can use that budget to hire professional editors and cover designers. Once your book is written and ready for edits and production, the template will come in handy since it’ll already be in a common format and file for you to start the book production and publishing process.Įven better – the book templates listed in this article are absolutely free. Using a book template, you’ll begin writing your book by typing your manuscript directly into your template. Select your book writing software, then you can find a book template that is already set up and formatted to get started writing. Whether you're writing a fiction book or a nonfiction book, you'll want to start writing as quickly as possible to reach your goal of becoming an author.Ī book template can help you do just that by saving you time from having to set up your own book file. This will save you a ton of wasted effort and formatting issues later on! ![]() If so, you’ll want to download a book layout template before you start typing up your manuscript. Do you need a book template to get started writing your book? 9/2/2023 0 Comments Online budget planner![]() Start by keeping track of what you spend in a month. With a zero-based budget, everything is on the table and you should have nothing left over. One popular strategy that businesses and individuals can use to get started involves making a zero-based budget. You won't know how much you can afford to trim from your budget if you don't have one at all. Maybe you're willing to cut back on some non-essential spending if it enables you to reach another goal. You can take a look at your budget and see what you can reasonably trim. Now, what if something changes down the road? Say you want to take a dream job that pays less than you're currently making or you want to move to a city with a higher cost of living. If that's within your budget, you've paid your bills and you've paid yourself, go for it. Say you know you're spending a hefty sum on eating out, travel or clothes. For another, you'll be able to make room in your budget if necessary. For one thing, you'll have an emergency fund and retirement savings. Once you have a workable budget you'll see how useful it can be to prepare you for the future. Having a budget that you regularly reassess will help you take stock of where your money is going and how close you are to meeting your goals. ![]() You "pay yourself" by beefing up your emergency fund and investing for retirement, you pay your bills (including any debts you're carrying) and then you can spend what's left over. But it's living from paycheck to paycheck in a good way. That may sound like living paycheck to paycheck and in a way it is. ![]() Ideally, every dollar of your income should be accounted for in a monthly budget. Let's talk about living within your means. Second, having a budget leaves you better prepared for changes in the future. First, it helps you live within your means. Having a budget is important for two reasons. Budgeting also lets you see how much you're spending in different categories. Household Budget BasicsĪ budget lets you manage how much you're spending relative to how much you're earning. With our interactive budget calculator you can see how people like you in your zip code are budgeting based on factors including the number of adults and children in the household and the size of the household's annual income. We offer advice on how to streamline your budget, how to fix your budget and how to stick to your budget. It’s best to have a Wedding Budget in place before you start it will help narrow down your options and make the wedding planning process smoother.Here at SmartAsset we talk a lot about budgets. Finding a venue, looking for wedding vendors, and creating a Guest List should be next on your Checklist. Setting your wedding budget is just the beginning. We know it’s easy to forget the wedding payment deadlines with so much going on, so you can integrate your budget with your Checklist to help take your stress level down a notch. Want a photo booth? Need sparklers? Just add it to the wedding budget. We make it simple to add your own categories and line items to the wedding budget. Once you’ve decided on the wedding budget, you’ll need to keep track of your wedding expenses and wedding payments. Having a specific wedding budget makes it easier to choose vendors, and it can also help determine how much to spend on your honeymoon. Setting the wedding budget can take some time, but once you nail it down, everything will fall into place. We’ll distribute amounts based on your total wedding budget, but you can customize numbers too. You can only find this free tracker on WeddingWire, and our template makes planning your wedding budget easy. Whether you’re deciding how to distribute your budget or keeping track of wedding payments, our unique budget tracker organizes everything in one spot. The wedding budget is often the most stressful part of wedding planning, but not anymore! Keeping your wedding spending organized is key, so it’s best to start early. ![]() Seamlessly manage your guest list and RSVPs for all of your wedding events. 9/2/2023 0 Comments Mint choco cookie fanartSubreddit snoo was made by u/Snook-Pook from here. OR CRAFTS NO EDITS OR CRAFTS ANNOUNCEMENT NO ANC.MENTS NO ANC.MENTS CR: KINGDOM NO CRK NO CRK CLEAR FILTER CLEAR FILTER OR MEMES ART NO ART NO ART PUZZLE WORLD NO PW NO PW BUG NO BUGS NO BUGS TIPS NO TIPS NO TIPS NOTICES/UPDATES NO NOT./UPDATES NO NOT./UPDATES EDITS OR CRAFTS NO ED. Search by Flairs DISCUSSIONS NO DISCUSSIONS NO DISCUSSIONS QUESTIONS NO QUESTIONS NO QUESTIONS VIDEOS NO VIDEOS NO VIDEOS MONTHLY THREADS NO M.THREADS NO M.THREADS OTHER OR MEMES NO OT. Note: This subreddit is a fan-run forum and is not moderated/owned with DEVSISTERS. Search "Cookie Run" in Spriter's/Sounds Resource for other games E.g.You can search "쿠키런 길드런 아레나" (means Cookie Run Guild Arena) followed by the arena number for alternate guides. Stats to level up Cookies (XP Jellies, Skill Powders required) Ovenbreak Running Tech: Beginner to Intermediate by /u/Pun-IntentionalĬRK Data Collection & Guide Sheet by Loser Squad Guild Exploration Guide and Cooking Recipes by Cookie Run Updates If you're unsure of a rule or wish to give feedback, you may message modmail. "Is my pull good" are to be kept within the Gacha Pull/Fluff Megathread. Since both Mint Choco and The Golden Guard share VA, I had to doodle this. Gacha pulls/luck-based draws or fluff like "Dying close to a potion" e.g. ![]() Refrain from spamming the subreddit with your posts within a short period of time. suggestive themes may be posted, but it needs to be marked as such. ![]() Art, videos, guides)ĭo not post R-18/explicitly sexual content. Always directly link/source to the original creator. Keep all posts related to Cookie Run, their spinoffs, DEVSISTERS or the community. Post invite links/IDs/Guilds/Friendly Runs only in the Megathreads. Collect cookies and bake opponents! All Weekly/Monthly Threads have been replaced by one singular Megathread! ![]() Welcome to r/Cookierun! This subreddit is dedicated to discussing the endless runner, and its RPG spinoff. It was scheduled to launch in 2021 and will replace the Hubble telescope as. About News Webb 2023 - Flickr Webb 2022 - Flickr First Images - Flickr Test/Eng. ![]() "I am confident the team will do everything they can to prepare Webb to explore our cosmic past," he wrote on Twitter. The James Webb Space Telescope launch date is the next big thing in astronomy. The James Webb Space Telescope (sometimes called Webb or JWST) is a large infrared telescope with a 6.5-meter primary mirror. NASA's science chief, Thomas Zurbuchen, said Monday it was important for NASA to ensure the telescope was healthy before its launch. NASA has had a difficult time testing them all on Earth in conditions that mimic the temperatures, pressure, and microgravity of deep space. Billions over budget and years behind schedule, the James Webb Space Telescope finally got off the ground Christmas Day, rocketing up from the European Space Agencys launch site in Kourou. NASA’s James Webb Space Telescope launches on Dec. This is an exceedingly complex process, and there are more than 300 single points of failure aboard the observatory. Since then, technical problems and delays have bedeviled the complex telescope.īuilding Webb has been difficult because its 6.5-meter mirror needs to unfurl itself once it reaches an orbit about 1.5 million kilometers from Earth. Astronomers are excited about the detection of a special molecule in space. A senior source at the space agency said this testing is currently running ahead of schedule and that, provided some serious issue is not identified, the December 22 launch date should stick.Īny setbacks now in Webb's progress toward launch feel especially painful because reaching this point has been such a long, long road. NASA's follow-on instrument to the wildly successful Hubble Space Telescope was originally due to launch about a decade ago, with a development cost of $1 billion. Webb telescope just found something unprecedented in the Orion Nebula. Engineering teams have completed additional testing confirming NASA’s James Webb Space Telescope is ready for flight, and launch preparations are resuming toward Webb’s target launch date of Wednesday, Dec. NASA said it will provide an update when the testing is completed at the end of this week. Webb telescope just found something unprecedented in the Orion Nebula. Longtime fans of the telescope are celebrating it as a Christmas. Thats exactly what the new and impressive James Webb Space Telescope, finally (re)scheduled for launch on December 25, 2021, promises just that. ![]() NASA is leading an anomaly review board to investigate and conduct additional testing to determine with certainty that the incident did not damage any part of the telescope. JWSTs launch date was December 25 from Europes Spaceport in Kourou, French Guiana. 9/2/2023 0 Comments Mr. bean and his daughter![]() To go from a one-off TV episode to three decades of international fame - to the point that a man will be flown from Pakistan to Zimbabwe on the basis of a tenuous resemblance - is entirely nuts, and could only happen due to a combination of technology being at a certain point and a largely mute character being able to cross cultural boundaries.Ītkinson himself has discussed his beloved status among immigrant families in Britain and second-language English speakers, comparing his slapstick to “an immigrant coming into a world in which he knows very little and having to acclimatize and adapt and adjust to enable him to live the life he wants to live.” The only characters that are even slightly comparable are from comic books and video games, and they’re all the product of huge teams of people and endless reinterpretations, not just one greying man in a tie. There probably won’t ever be another comedy character that becomes a global icon in the same way as Mr. Bean, go and check it out.”) It’s Never Bean Like This Bean TikTok account has four million followers, there’s also a very sketchy fake “official” account in Rowan Atkinson’s name with the bio, “ What’s up guys this is the official account of Rowan Atkinson, I’m an actor in Mr. Bean) because he is internationally successful.”Įnglishman Lewis John, known as “Bean Reborn” on TikTok, has a million followers and completely nails the voice, although his visual resemblance to the original ends at “Caucasian male.” (While the official Mr. Translation search engine Youdao mentions his international success (in kind of a bitchy way) on its page for him, giving the sample sentence, “ British people resent Rowan Atkinson (Mr. At one point, Shanghai had not one but two Mr Bean-themed coffee shops. He’s been used in animated form - without permission - in government propaganda videos about the importance of protecting state secrets, alongside Spider-Man and Hitler. While international audiences were embracing Jackie Chan, Chinese audiences took Mr. This saw an influx of international shows, and nothing travels like slapstick. His peak years, the early 1990s, coincided with both mass TV purchasing in China and a slight relaxing in government control over what was broadcast on those televisions. Bean millions? China’s Clumsy COVID CorrespondentĬhina loves Mr. So if you were a slightly rubbery-looking dude with access to a tweed jacket and a teddy bear, why wouldn’t you jump on those sweet, sweet Mr. It’s an easy costume, and a character that transcends basically all barriers. Bean lookalikes - people who vaguely resemble him monetizing that vague resemblance, sometimes to pretty lucrative results. ![]() As such, there’s an international cottage industry of Mr. Naturally, this means that all over the world, people have tried to make a few bucks off of him. ![]() If you live within a mile of a TV, you’ve seen him. Bean walked in, everyone would shit their fucking pants. If Dwayne “The Rock” Johnson walked into a rural village in the middle of nowhere, people would be excited. When we think of global icons, we tend to think of people who are a bit cooler or sexier, but this dude is huge. Over 30 years, there have been two movies, an animated series, several books, an appearance at the Olympics, a starring role in British Airways’ safety videos and endless cameos, ads and one-off spots.Īll of which is to say, Mr. The episodes were sold to TV networks across the globe, and the character reached a kind of language-transcendent status. A combination of Rowan Atkinson ’s incredible performance and a minimal use of dialogue meant Bean’s slapstick antics became a worldwide success, a mainstay of in-flight entertainment systems in the days of one chunky CRT monitor at the front of the cabin. While only 15 half-hour episodes of the original series were made over a five-year period from 1990 to 1995, the character became an instant comedy icon. |
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